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pentobarbital will lessen the extent or effect of eplerenone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.pentobarbital will lower the extent or impact of hydrocortisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital increases toxicity of buprenorphine, long-perform